Table 1.

Performance of Sonographic Markers in Predicting Fetal Hb Bart’s Disease.

	Study	Gestational Age (Week)	Cut-Off Value	Sensitivity (%)	Specificity (%)	References
Potential biomarkers	Cardio-thoracic diameter ratio	12–15	≥0.50	75–100	90–100	[18,46,47,48,49,50,59]
		18–22	≥0.52	88–100	87–96
	Middle cerebral artery—peak systolic velocity	12–15	≥1.5 MoM	17–56	79–96	[48,49,53]
		16–22	≥1.5 MoM	64–85	98–100
	Placental thickness	12–15	≥18 mm	72.9	68.8	[48,49,52]
		18–22	≥30 mm	74–100	96.1
Other additional biomarkers	Thickened nuchal translucency	11–14	>95th percentile	16.7	98.6	[49]
	Cardio-biparietal diameter ratio	17–22	≥0.45	84–91	77–93	[60,61]
	Cardiac circumference	15–22	1.17 MoM	86.4	78.1	[57]
	Global sphericity index	18–22	1.17	74.1	88.2	[62]
	Liver length	18–22	≥27.0 mm	71.3	95.5	[54]
	Splenic circumference	18–22	≥1.5 MoM	70.1	83.0	[63]
	Splenic artery—peak systolic velocity	18–22	≥1.51 MoM	84.4	98.1	[55]

Abbreviation: MoM, multiples of the median.