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The direct and indirect effect of IMiDs on MM. IMiDs enhances apoptosis and inhibits MM proliferation through the cyclin-dependent pathway. IMiDs works indirectly through activating the immune cells. CRBN: Cereblon, DDB1: DNA damage-binding protein 1, CUL4: Cullin-4A, and ROC1: RING box protein-1. Created by Biorender.com.
