Skip to main content
PMC home page
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1995 May;54(5):417–423. doi: 10.1136/ard.54.5.417

Fluid movement across synovium in healthy joints: role of synovial fluid macromolecules.

J R Levick 1, J N McDonald 1
PMCID: PMC1005608  PMID: 7794053

Full text

PDF
419

Images in this article

419Image
on p.419
422Image
on p.422

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson J. L., Malone D. M. Mechanism of osmotic flow in porous membranes. Biophys J. 1974 Dec;14(12):957–982. doi: 10.1016/S0006-3495(74)85962-X. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Aukland K., Reed R. K. Interstitial-lymphatic mechanisms in the control of extracellular fluid volume. Physiol Rev. 1993 Jan;73(1):1–78. doi: 10.1152/physrev.1993.73.1.1. [DOI] [PubMed] [Google Scholar]
  3. Brown T. J., Laurent U. B., Fraser J. R. Turnover of hyaluronan in synovial joints: elimination of labelled hyaluronan from the knee joint of the rabbit. Exp Physiol. 1991 Jan;76(1):125–134. doi: 10.1113/expphysiol.1991.sp003474. [DOI] [PubMed] [Google Scholar]
  4. Comper W. D., Zamparo O. Hydraulic conductivity of polymer matrices. Biophys Chem. 1989 Oct;34(2):127–135. doi: 10.1016/0301-4622(89)80050-x. [DOI] [PubMed] [Google Scholar]
  5. Goldsmith H. L., Cokelet G. R., Gaehtgens P. Robin Fåhraeus: evolution of his concepts in cardiovascular physiology. Am J Physiol. 1989 Sep;257(3 Pt 2):H1005–H1015. doi: 10.1152/ajpheart.1989.257.3.H1005. [DOI] [PubMed] [Google Scholar]
  6. Jensen L. T., Henriksen J. H., Olesen H. P., Risteli J., Lorenzen I. Lymphatic clearance of synovial fluid in conscious pigs: the aminoterminal propeptide of type III procollagen. Eur J Clin Invest. 1993 Dec;23(12):778–784. doi: 10.1111/j.1365-2362.1993.tb00731.x. [DOI] [PubMed] [Google Scholar]
  7. Knight A. D., Levick J. R., McDonald J. N. Relation between trans-synovial flow and plasma osmotic pressure, with an estimation of the albumin reflection coefficient in the rabbit knee. Q J Exp Physiol. 1988 Jan;73(1):47–65. doi: 10.1113/expphysiol.1988.sp003122. [DOI] [PubMed] [Google Scholar]
  8. Knox P., Levick J. R., McDonald J. N. Synovial fluid--its mass, macromolecular content and pressure in major limb joints of the rabbit. Q J Exp Physiol. 1988 Jan;73(1):33–45. doi: 10.1113/expphysiol.1988.sp003121. [DOI] [PubMed] [Google Scholar]
  9. Levick J. R. A two-dimensional morphometry-based model of interstitial and transcapillary flow in rabbit synovium. Exp Physiol. 1991 Nov;76(6):905–921. doi: 10.1113/expphysiol.1991.sp003553. [DOI] [PubMed] [Google Scholar]
  10. Levick J. R. An analysis of the interaction between interstitial plasma protein, interstitial flow, and fenestral filtration and its application to synovium. Microvasc Res. 1994 Jan;47(1):90–125. doi: 10.1006/mvre.1994.1007. [DOI] [PubMed] [Google Scholar]
  11. Levick J. R. Flow through interstitium and other fibrous matrices. Q J Exp Physiol. 1987 Oct;72(4):409–437. doi: 10.1113/expphysiol.1987.sp003085. [DOI] [PubMed] [Google Scholar]
  12. Levick J. R., Knight A. D. Interaction of plasma colloid osmotic pressure and joint fluid pressure across the endothelium-synovium layer: significance of extravascular resistance. Microvasc Res. 1988 Jan;35(1):109–121. doi: 10.1016/0026-2862(88)90054-4. [DOI] [PubMed] [Google Scholar]
  13. Levick J. R., McDonald J. N. Ultrastructure of transport pathways in stressed synovium of the knee in anaesthetized rabbits. J Physiol. 1989 Dec;419:493–508. doi: 10.1113/jphysiol.1989.sp017882. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Levick J. R., McDonald J. N. Viscous and osmotically mediated changes in fluid movement across synovium in response to intraarticular albumin. Microvasc Res. 1994 Jan;47(1):68–89. doi: 10.1006/mvre.1994.1006. [DOI] [PubMed] [Google Scholar]
  15. Levick J. R., Smaje L. H. An analysis of the permeability of a fenestra. Microvasc Res. 1987 Mar;33(2):233–256. doi: 10.1016/0026-2862(87)90020-3. [DOI] [PubMed] [Google Scholar]
  16. McDonald J. N., Levick J. R. Hyaluronan reduces fluid escape rate from rabbit knee joints disparately from its effect on fluidity. Exp Physiol. 1994 Jan;79(1):103–106. doi: 10.1113/expphysiol.1994.sp003736. [DOI] [PubMed] [Google Scholar]
  17. Parker K. H., Winlove C. P. The macromolecular basis of the hydraulic conductivity of the arterial wall. Biorheology. 1984;21(1-2):181–196. doi: 10.3233/bir-1984-211-221. [DOI] [PubMed] [Google Scholar]
  18. Rippe B., Haraldsson B. Transport of macromolecules across microvascular walls: the two-pore theory. Physiol Rev. 1994 Jan;74(1):163–219. doi: 10.1152/physrev.1994.74.1.163. [DOI] [PubMed] [Google Scholar]
  19. Simkin P. A., Benedict R. S. Iodide and albumin kinetics in normal canine wrists and knees. Arthritis Rheum. 1990 Jan;33(1):73–79. doi: 10.1002/art.1780330109. [DOI] [PubMed] [Google Scholar]
  20. Stevens C. R., Blake D. R., Merry P., Revell P. A., Levick J. R. A comparative study by morphometry of the microvasculature in normal and rheumatoid synovium. Arthritis Rheum. 1991 Dec;34(12):1508–1513. doi: 10.1002/art.1780341206. [DOI] [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES