Table 1.
Baseline clinical features and treatment regimens in 12,327 patients with pancreatic cancer.
| Variables | n (%) | Without LM Cohort n (%) | With LM Cohort n (%) | p |
|---|---|---|---|---|
| Age | 12,327 | 10,429 | 1898 | |
| ≤49 | 1043 (8.5) | 870 (8.3) | 173 (9.1) | 0.088 |
| 50–64 | 4294 (34.8) | 3602 (34.5) | 692 (36.5) | |
| 65–74 | 4032 (32.7) | 3417 (32.8) | 615 (32.4) | |
| ≥75 | 2958 (24.0) | 2540 (24.4) | 418 (22.0) | |
| Sex | ||||
| Female | 6029 (48.9) | 5187 (49.7) | 842 (44.4) | <0.001 |
| Male | 6298 (51.1) | 5242 (50.3) | 1056 (55.6) | |
| Race | ||||
| Black | 1586 (12.9) | 1281 (12.3) | 305 (16.1) | <0.001 |
| Other | 1066 (8.6) | 921 (8.8) | 145 (7.6) | |
| White | 9675 (78.5) | 8227 (78.9) | 1448 (76.3) | |
| Primary sites | ||||
| Other | 1686 (13.7) | 1320 (12.7) | 366 (19.3) | <0.001 |
| Pancreatic body tail | 3552 (28.8) | 2820 (27.0) | 732 (38.6) | |
| Pancreatic head | 7089 (57.5) | 6289 (60.3) | 800 (42.1) | |
| Histopathology | ||||
| Adenocarcinoma | 6555 (53.2) | 5243 (50.3) | 1312 (69.1) | <0.001 |
| Infiltrating duct carcinoma | 3173 (25.7) | 3028 (29.0) | 145 (7.6) | |
| Neuroendocrine carcinoma | 1160 (9.4) | 923 (8.9) | 237 (12.5) | |
| Other | 1439 (11.7) | 1235 (11.8) | 204 (10.7) | |
| Grade | ||||
| I (Well) | 2673 (21.7) | 2439 (23.4) | 234 (12.3) | <0.001 |
| II (Moderately) | 5244 (42.5) | 4551 (43.6) | 693 (36.5) | |
| III (Poorly) | 4172 (33.8) | 3263 (31.3) | 909 (47.9) | |
| IV (Undifferentiated) | 238 (1.9) | 176 (1.7) | 62 (3.3) | |
| T stage | ||||
| T1 | 1246 (10.1) | 1172 (11.2) | 74 (3.9) | <0.001 |
| T2 | 2223 (18.0) | 1648 (15.8) | 575 (30.3) | |
| T3 | 7331 (59.5) | 6521 (62.5) | 810 (42.7) | |
| T4 | 1527 (12.4) | 1088 (10.4) | 439 (23.1) | |
| N stage | ||||
| N0 | 6158 (50.0) | 5097 (48.9) | 1061 (55.9) | <0.001 |
| N1 | 6169 (50.0) | 5332 (51.1) | 837 (44.1) | |
| Bone metastasis | ||||
| No | 12,194 (98.9) | 10,387 (99.6) | 1807 (95.2) | <0.001 |
| Yes | 133 (1.1) | 42 (0.4) | 91 (4.8) | |
| Brain metastasis | ||||
| No | 12,316 (99.9) | 10,423 (99.9) | 1893 (99.7) | 0.019 |
| Yes | 11 (0.1) | 6 (0.1) | 5 (0.3) | |
| Lung metastasis | ||||
| No | 11,895 (96.5) | 10,245 (98.2) | 1650 (86.9) | <0.001 |
| Yes | 432 (3.5) | 184 (1.8) | 248 (13.1) | |
| Tumor size | ||||
| ≤2 cm | 2099 (17.0) | 1978 (19.0) | 121 (6.4) | <0.001 |
| 2–4 cm | 5933 (48.1) | 5213 (50.0) | 720 (37.9) | |
| >4 cm | 3848 (31.2) | 2935 (28.1) | 913 (48.1) | |
| Unknown | 447 (3.6) | 303 (2.9) | 144 (7.6) | |
| Surgery | ||||
| No | 3708 (30.1) | 2153 (20.6) | 1555 (81.9) | <0.001 |
| Yes | 8619 (69.9) | 8276 (79.4) | 343 (18.1) | |
| Radiotherapy | ||||
| None/Unknown | 9502 (77.1) | 7725 (74.1) | 1777 (93.6) | <0.001 |
| Yes | 2825 (22.9) | 2704 (25.9) | 121 (6.4) | |
| Chemotherapy | ||||
| None/Unknown | 4972 (40.3) | 4270 (40.9) | 702 (37.0) | 0.001 |
| Yes | 7355 (59.7) | 6159 (59.1) | 1196 (63.0) |