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. Author manuscript; available in PMC: 2023 Mar 29.
Published in final edited form as: J Med Chem. 2023 Jan 25;66(3):2116–2142. doi: 10.1021/acs.jmedchem.2c01894

Figure 1.

Figure 1.

Examples of structures that target the ClpXP protease system. The rings A, B, and C of 334 are color coded as indicated above. (aBortezomib can exert an activating effect on ClpP depending on its concentration.54).