Skip to main content
. Author manuscript; available in PMC: 2023 Mar 29.
Published in final edited form as: J Med Chem. 2023 Jan 25;66(3):2116–2142. doi: 10.1021/acs.jmedchem.2c01894

Scheme 1. Synthesis of Dihydrothiazepines Containing Modifications on Ring Aa.

Scheme 1.

a(a) l-Proline, MeOH, room temperature (RT), molecular sieve (MS) 4 Å, 16–20 h; (b) isopropanol (iPrOH)/HOAc or p-toluenesulfonic acid (pTsOH)/iPrOH, RT, MS 4 Å, 18–24 h.