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. Author manuscript; available in PMC: 2023 Mar 29.
Published in final edited form as: J Med Chem. 2023 Jan 25;66(3):2116–2142. doi: 10.1021/acs.jmedchem.2c01894

Scheme 4. Synthesis of Dihydrothiazepines Containing Modification on Ring B and Diazepine Derivativesa.

Scheme 4.

a (a) iPrOH, RT, MS 4 Å, 18–24 h; (b) iPrOH/HOAc or pTsOH/iPrOH, N2(g), RT, MS 4 Å, 18–24 h.