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. Author manuscript; available in PMC: 2023 Mar 29.
Published in final edited form as: J Med Chem. 2023 Jan 25;66(3):2116–2142. doi: 10.1021/acs.jmedchem.2c01894

Figure 7.

Figure 7.

Inhibition of ClpX ATPase activity. Recombinant ClpX was incubated with either the inhibitor or DMSO as a solvent control. Reactions were halted by the addition of Kinase-Glo at 60 min and the remaining levels of ATP were determined by measuring luminescence as a marker for ClpX ATPase activity. The columns represent the amount of ATP depleted over time versus the ATP only control. Error bars report SEM. Each experiment included technical replicates and at least three biological replicates. **P ≤ 0.01; ****P ≤ 0.0001; by one-way analysis of variance (ANOVA), Tukey correction.