Table 1.

Chemical Structures of Dihydrothiazepine Derivatives 5a–v and Their IC₅₀ against C. trachomatis Serovar L2^a

compound	R1	R2	R3	IC50 (μg/mL)b,c
5a	CN	H	H	1.61 ± 0.11
5b	OCH3	H	H	3.32 ± 0.51
5c	F	CH3	H	4.69 ± 1.20
5d	H	Cl	H	4.79 ± 0.19
5e	H	CF3	H	5.18 ± 1.67
5f	H	NO2	H	6.35 ± 0.70
5g	Cl	H	Cl	6.37 ± 0.67
5h	H	H	Cl	6.59 ± 0.18
	H	H	CH3	6.72 ± 0.58
5j	H	H	OC(O)CH3	7.18 ± 0.50
5k	H	H	OCF3	7.44 ± 0.30
5l	H	H	Br	7.50 ± 1.01
5m	H	CN	H	9.00 ± 1.15
5n	H	H	NO2	9.01 ± 0.25
5o	H	H	CN	10.21 ± 1.47
5P	H	H	OH	14.41 ± 2.76
5q	H	H	OCH3	14.69 ± 1.26
334	H	OH	H	16.53 ± 0.65
6a	H	H	NH2	17.63 ± 0.43
5s	H	H	OCH2Ph	22.76 ± 0.34
5t	H	H	CO2H	NI
5u	CO2H	H	H	NI
5v	H	H	Ph	NI

^aIC₅₀ indicates 50% inhibition of control Chlamydia inclusions. NI: no inhibition seen at the tested concentration range (25–0.39 μg/ mL).

^bAll assays were performed in triplicate.

^cIC₅₀ values are also presented in μM and pIC₅₀ units in Table S1. The presented data corresponds to mean ± standard deviation (SD).