Table 5.
Antimicrobial Activity Panel of Compound 5a
| MICp (μg/mL) |
|||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Saa | Abb | Ecc | Pad | Ece | Lrf | Lpg | BPh | Cri | Btj | Ack | Cal | Ccm | Ckn | Cto | |
| 5a | >125 | >125 | >125 | >125 | >125 | >125 | >125 | >125 | >125 | >125 | >125 | >1000 | >1000 | >1000 | >1000 |
| AZM q | 2 | <1 | <1 | 125 | 2 | 1 | 2 | <0.06 | <0.06 | 0.5 | >125 | ner | ne | ne | ne |
| FCZ s | ne | ne | ne | ne | ne | ne | ne | ne | ne | ne | ne | 1 | 2 | 16 | 0.5 |
a
S. aureus USA 300 JE2.
b
Acinetobacter baumannii 2208.
c
Escherichia coli K12.
d
Pseudomonas aeruginosa PA01.
e
E. coli nonpathogenic ATCC MG1655.
f
Lactobacillus rhamnosus CGMCC 1.3724.
g
Lactobacillus plantarum DSM 20174.
h
Blautia producta DSM 2950.
i
Clostridium ramosum DSM 1402.
j
Bacteroides thetaiotaomicron DSM 2079.
k
Anaerostipes caccae DSM 14662.
l
Candida albicans 90028.
m
Candida glabrata 2001.
n
Candida krusei 6558.
o
Candida tropicalis 750.
p
MIC: minimum inhibitory concentration (μg/mL).
q
AZM: azithromycin.
r
ne: not evaluated.
s
FCZ: fluconazole.