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. 2023 Feb 21;11(3):199. doi: 10.3390/toxics11030199

Figure 1.

Figure 1

AOPs reporting Ag NPs as a potential stressor. Four AOPs showing Ag NPs as stressors were analyzed in terms of their molecular initiating events (MIE, green boxes), key events (KE, yellow boxes) and adverse outcomes (AO, orange boxes) [38,39,40,41]. This led to the identification of several pathways that are shared among these AOPs (highlighted in grey), focusing on oxidative stress, DNA damage and repair, and apoptosis. These pathways served as the basis of our AOP-oriented Ag NP toxicity-testing strategy.