Table 2.
Expression of neurotrophins in study’s participants.
| mRNA BDNF | proBDNF Protein | BDNF Protein | |
|---|---|---|---|
| IBD | (n = 80); 655.70 (2.36–2850.57) | (n = 80); 14.69 (10.46–17.74) | (n = 80); 80; 25.36 (20.39–33.67) |
| HC | (n = 44); 1325.99(765.48–2261.07) | (n = 44); 11.56 (7.370–16.52) | (n = 44); 19.04(13.16–26.80) |
| p | 0.008 | <0.001 | 0.008 |
| CD | (n = 49); 908.73 (17.06–3450.79) | (n = 49); 15.30(11.48–17.51) | (n = 49); 23.11(18.18–30.14) |
| UC | (n = 31); 306.07 (1.83–1830.11) | (n = 31); 13.31 (10.06–18.11) | (n = 31); 28.92 (23.65–37.89) |
| p | 0.218 | 0.366 | 0.007 |
| Ex | (n = 47); 605.81 (1.82–3088.55) | (n = 47); 14.71 (10.34–17.49) | (n = 47); 25.00 (20.05–33.16) |
| R | (n = 33); 705.60(2.81–1830.11) | (n = 33); 14.54 (10.86–18.47) | (n = 33); 27.37(21.00–34.17) |
| p | 0.977 | 0.431 | 0.566 |
| Ex | (n = 47); 605.81 (1.83–3088.55) | (n = 47); 14.71(10.34–17.49) | (n = 47); 25.00(20.05–33.16) |
| HC | (n = 44); 1325.99(765.48–2261.07) | (n = 44); 11.58 (7.37–16.52) | (n = 44); 19.04 (13.16–26.80) |
| p | 0.025 | 0.043 | 0.002 |
| R | (n = 33); 705.60 (2.81–1830.11) | (n = 33); 14.54(10.86–18.47) | (n = 33); 27.37(21.00–34.17) |
| HC | (n = 44); 1325.99(765.48–2261.07) | (n = 44); 11.58(7.37–16.52) | (n = 44); 19.04 (13.16–26.80) |
| p | 0.019 | 0.009 | <0.001 |
Abbreviations: BDNF—Brain-Derived Neurotrophic Factor, CD—Crohn’s Disease, Ex—Exacerbation, UC—Ulcerative Colitis, HC—Healthy Controls, IBD—Inflammatory Bowel Disease, proBDNF—BDNF precursor, R—Remission. Data are presented as n; median (IQR). Bolded text indicates statistically significant differences (p < 0.05).