Table 3.
Examples of SLNs formulation for cancer treatment in different stages of development.
| Lipid | Method | Drug | Cancer | Phase | Ref |
|---|---|---|---|---|---|
| SA | Hot sonication | Wogonin | BC | In vitro | [78] |
| SA | Emulsification-solidification | Curcumin | BC | In vitro | [79] |
| SA & lecithin & TPGS | Emulsification-solidification | Resveratrol | BC | In vivo | [71] |
| CP | SEE | Nutlin3 & SPIONS | GBM | In vitro (BBB model) | [74] |
| Trilaurin | Microemulsion cold dilution | Curcumin | PC | In vivo | [81] |
| Gliceryl tripalmitate | HSH | PTX | BC and LC | In vitro | [67] |
| Resveratrol-stearated | Microemulsion | Omg-3 | CRC | In vitro | [82] |
| SA | HSH | TMX | BC | In vitro | [72] |
| Lauric acid & (linoleic acid/oleic acid) | Hot melt encapsulation | 5-FU | BC | In vitro | [76] |
| Sodium behenate | Coacervation | TMZ | Melanoma | In vivo | [68] |
| Behenic acid sodium salt | Coacervation | DOX | OC | In vitro | [73] |
| SA | SEE | Curcumin | HL | In vivo | [80] |
| Trilauriun & TPGS | Microemulsion | DOX and SPIONS | PTC (murine) | In vivo | [75] |
| CP | HPH | Indirubin | GBM | In vitro | [83] |
| CP | SEE | Topotecan hydrocloride | CC | In vitro | [84] |
| GMS | HSH | Talazoparib (BMN673) | BC | In vitro | [85] |
| Myristyl myristate | Hot sonication | Linalool | HC and LC | In vitro | [86] |
| GMS | Hot sonication | PTX and ascorbyl palmitate | Melanoma (murine) | In vivo | [87] |
| SA & lecithin | SIL | 5-FU | Melanoma | In vivo | [88] |
| Compritol® | Microemulsion | AP9-cd (ligand) | Leukaemia | In vivo | [89] |
| 1-tetradecanol | HHPH and ultrasonication | Temoporfin | BC | In vivo | [90] |
| GMS, AAD, and RGD | Emulsification-solidification | DOX | BC | In vivo | [77] |
| SA | SED | PTA | OC | In vitro | [91] |
| Precirol® ATO5 | Emulsification-solidification | PTX | BC | In vitro | [92] |
| Imwitor® 308 and Dynasan® 114 | Ultrasonic melt-emulsification | Celecoxib | CRC | In vitro | [93] |
| Lecithin & DSPE-PEG2000 | Film dispersion method | PTX, Curcumin | LC | In vivo | [94] |
| GMS | modified emulsion/solvent evaporation method | Abiraterone Acetate | PC | Ex vivo/In vivo | [95] |
Abbreviations: Lipid: Stearic Acid (SA), DL-α-Tocopherol methoxypolyethylene glycol succinate (TPGS), Cetyl Palmitate (CP), Glycerol Monostearate (GMS), Adipic acid dihydrazide (AAD), Arginine-Glycine-Aspartic (RDG). Method: Microwave-Assisted Microemulsion Technique (MAMT), Solvent Emulsification-Evaporation (SEE), High Shear Homogenization (HSH), Solvent Injection-Lyophilization (SIL), Hot High-Pressure Homogenization (HHPH), Solvent Emulsification-Diffusion (SED). Drug: Paclitaxel (PTX), Tamoxifen (TMX), 5-fluorouracil (5-FU), Temozolomide (TMZ), Superparamagnetic iron oxide nanoparticles (SPIONs), Doxorubicin hydrochloride (DOX), 1,3,5-triaza-7-phosphaadamantane (PTA). Cancer: Breast Cancer (BC), Glioblastoma (GBM), Prostate Cancer (PC), Lung Cancer (LC), Colorectal Cancer (CRC), Ovarian Cancer (OC), Hodgkin’s Lymphoma (HL), Papillary Thyroid Cancer (PTC), Prostate Carcinoma (PC), Cervical Cancer (CC), Hepatocarcinoma (HC).