Table 5.
SLNs with different genetic material for different cancer types in different stages of development. N.A.—not applicable.
| Lipid | Method | Drug | Genetic Material | Cancer | Phase | Ref |
|---|---|---|---|---|---|---|
| Gelucire® 50/13 | SEE | PTX | Bcl-2 siRNA | CC | In vitro | [136] |
| Precirol ATO5 and Compritol® | Microemulsion (modified) | N.A. | pDNA stat3 | LC | In vitro | [134] |
| Steryalmide | Microemulsion | Sorafenib/ATRA | miR-542-3p | GC | In vivo | [138] |
| DSPE, DOTAP, and αPC | SED | Irinotecan | miR200 | CRC | In vivo | [141] |
| DOPE, Chol, and DC-Chol | SEE | N.A. | c-Met siRNA | GBM | In vivo | [132] |
| DOPC | emulsification solidification methods | PTX | MCL-1 siRNA | BC | In vivo | [137] |
| GMS | film-ultrasonic dispersion method | PTX | pDNA | BC | In vivo | [140] |
| Precirol ATO5 | ethanolic precipitation technique & HPH | N.A. | shNUPR1 | HC | In vitro | [133] |
| DOTAP and GMS | SED | N.A. | miR200 | BC | In vitro | [142] |
| GMS, SPC, and Chol | film-ultrasonic method | N.A. | miR-34a | LC | In vivo | [143] |
| GMS and SPC | SED | N.A. | AMO | LC | In vitro | [144] |
| GMS and soya lecithin | solvent diffusion method | N.A. | STAT3 decoy oligodeoxynucleotides | OC | In vivo | [135] |
| Cetyl palmitate and Cremephor RH 40, Peceol, and propylene glycol | melt-emulsification technique | N.A. | siRNA-EGFR siRNA-PD-L1 |
GBM | In vivo | [145] |
Abbreviations: Lipid: 3β-[N-(N′,N′-dimethylaminoethane)-carbamoyl]-cholesterol (DC-Chol), 1,2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE), 1,2-Dioleoyl-3-trimethylammonium propane (DOTAP), l-α-Phosphatidylcholine (αPC), 1,2-Dioleoyl-sn-glycero-3-phosphocholine (DOPC), Glycerol Monostearate (GMS), Soy phosphatidylcholine (SPC). Stearic Acid (SA), Glycerol Monostearate (GMS), Palmitic acid (PA), DL-α-Tocopherol methoxypolyethylene glycol succinate (TPGS), Soy phosphatidylcholine (SPC), Octadecylamine (Oda), Cardiolipin (CL), Hydrogenated soya phosphatidylcholine (HSPC). Method: High Shear Homogenization (HSH), Hot High-Pressure Homogenization (HHPH), Solvent Emulsification-Evaporation (SEE), Solvent Emulsification-Diffusion (SED), Solvent Injection (SI). Drug: Paclitaxel (PTX), α-tocopherol succinate-cisplatin (TSC), Doxorubicin hydrochloride (DOX), Superparamagnetic iron oxide nanoparticles (SPIONs), Etoposide (ETP). Cancer: Cervical Cancer (CC), Lung Cancer (LC), Gastric Cancer (GC), Colorectal Cancer (CRC), Glioblastoma (GBM), Breast Cancer (BC), Hepatocarcinoma (HC), Ovarian Cancer (OC).