Table 5.
Comparison of ECG characteristics and criteria of the validation cohort based on Brugada syndrome diagnosis after Sodium Channel Blocker Provocation Test.
| Overall (n = 197) |
Negative SCBPT (n = 150) |
Positive SCBPT (n = 47) |
p Value | |
|---|---|---|---|---|
| Heart rate, bpm | 73.9 ± 15.1 | 73.7 ± 15.1 | 70.1 ± 14.8 | 0.150 |
| p-wave, ms | 103.8 ± 12.7 | 103.4 ± 12.4 | 105.2 ± 13.8 | 0.392 |
| PR interval, ms | 158.6 ± 24.7 | 157.9 ± 23.5 | 161 ± 28.3 | 0.451 |
| QRS duration, ms | 97.8 ± 9.1 | 97.2 ± 6.2 | 99.7 ± 15.1 | 0.104 |
| QT interval, ms | 385.8 ± 28.3 | 385.6 ± 25.9 | 386.3 ± 35.1 | 0.890 |
| QTc interval, ms | 416.2 ± 30.8 | 417.6 ± 33.2 | 411.9 ± 21.1 | 0.280 |
| P axis, ° | 55.5 ± 20.1 | 57.2 ± 21.7 | 50.1 ± 12.1 | 0.06 |
| QRS axis, ° | 40.1 ± 34.5 | 43.3 ± 34.3 | 30.6 ± 33.7 | 0.06 |
| T axis, ° | 44.3 ± 20.8 | 45.8 ± 28.9 | 39.7 ± 20.1 | 0.079 |
| Measurability of r’-wave at: | ||||
| IV° ic, % (n) | 11.2 (22) | 6 (9) | 27.7 (13) | <0.0001 |
| III° ic, % (n) | 27.9 (55) | 18 (27) | 59.6 (28) | <0.0001 |
| II° ic, % (n) | 34 (67) | 22.7 (34) | 70.2 (33) | <0.0001 |
| Major β- angle | 41.4 ± 15.5 | 32.9 ± 8.7 | 50.4 ± 16.2 | <0.0001 |
| Major α- angle | 30.8 ± 12.4 | 24.6 ± 6.9 | 37.6 ± 13.5 | <0.0001 |
| Major DBT- 5 mm | 151.3 ± 85.9 | 115.4 ± 54.5 | 189.2 ± 97.1 | <0.0001 |
| Major DBT- iso | 89.9 ± 46.9 | 69.8 ± 20.5 | 112 ± 57.1 | <0.0001 |
| Major triangle base/height | 1.2 ± 0.7 | 1.1 ± 0.6 | 1.3 ± 0.7 | 0.03 |