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. 2023 Mar 16;24(6):5705. doi: 10.3390/ijms24065705

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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COA6 regulates the production of ATP in LUAD cells (A549 and H1975). (A,E) Line graphs showing the impact on OCR by OLI and Rtn/AA in different groups; (B,F) The histograms showing that knockdown of COA6 decreased ATP produced by mitochondrial OXPHOS (mean ± SD, n = 3); (C,G) The histograms showing that knockdown of COA6 did not decrease ATP produced by glycolysis significantly in A549 cells, but decreased ATP produced by glycolysis significantly in H1975 cells (mean ± SD, n = 3); (D,H) The histograms showing that knockdown of COA6 decreased total ATP in LUAD cells (mean ± SD, n = 3). OCR, oxygen consumption rate; OLI, oligomycin; Rtn/AA, Rotenone/Antimycin A. Independent samples t-test was used in comparing the means of two groups, * p < 0.05, ** p < 0.01, and *** p < 0.001.