Table 2.
Experimental vaccines using Capripoxvirus as a live virus vector.
| Target Pathogen | Antigen Expressed | Capripoxvirus Backbone | Reference |
|---|---|---|---|
| Rindepest Virus | Rindepest Virus H and F gene | KS-1 * | [122] |
| Peste-des-petits-ruminants virus (PPRV) | hemagglutinin (H) or the fusion (F) protein gene of PPRV | KS-1 * | [118] |
| Blue Tongue Virus (BTV) | BTV VP7 | KS-1 * | [119] |
| Rift Valley Fever Virus (RVFV) | RVFV Gn and Gc glycoproteins | KS-1 * | [117] |
| HIV | Grttn polyprotein | nLSDV | [106,123] |
| Env and Gag | nLSDV with SODis | [105] | |
| Rabies virus (RABV) | RABV Glycoprotein | nLSDV | [6] |
| Mokola virus (MOKV), West Caucasian bat virus (WCBV), Rabies Virus (RABV) | RABV, MOKV and WCBV glycoprotein genes | nLSDV | [121] |
| Rift valley fever virus (RVFV) | RVFV Gn and Gc glycoproteins | nLSDV | [102,124,125] |
| Bovine ephemeral fever virus (BEFV) | BEFV Glycoprotein | nLSDV | [102,124,125] |
| Glycoprotein | nLSDV with either SODis or ΔSOD | [104] | |
| Glycoprotein and Matrix |
nLSDV: Neethling strain of LSDV; SODis: stabilised superoxide dismutase gene; ΔSOD: deleted superoxide dismutase gene. * KS-1 was originally thought to be of SPPV origin, but sequencing revealed that it was actually an LSDV derived vaccine [120].