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. 2023 Mar 18;24(6):5815. doi: 10.3390/ijms24065815

Figure 2.

Figure 2

Changes in normalized gene expression levels in lens-induced myopia (LIM) mice administered lactoferrin (LF) and its derivatives. Calculations were performed using the ratio −30 D ∆∆CT/0 D ∆∆CT. (a) Interleukin (IL)-1, tumor necrosis factor (TNF)-α, and matrix metalloprotease (MMP)-2 mRNA expression level ratios in the sclera. (b) IL-6, IL-8, and vascular endothelial growth factor (VEGF) A mRNA expression level ratios in the choroid. n = 10 per group. * p < 0.05, ** p < 0.01, *** p < 0.001 and **** p < 0.0001. Comparisons between PBS, LF, pepsin + LF, trypsin + LF groups in each experiment were analyzed by analysis of variance and Tukey’s post hoc test. The values are represented as mean ± SE.