Figure 4.

Changes in normalized gene expression levels in lens-induced myopia (LIM) mice administered lactoferrin (LF) and Holo-LF. Calculations were performed using the ratio −30 D ∆∆CT/0 D ∆∆CT. (a) Interleukin (IL)-1, tumor necrosis factor (TNF)-α, and matrix metalloprotease (MMP)-2 mRNA expression level ratios in the sclera. (b) IL-6, IL-8, and vascular endothelial growth factor (VEGF) A mRNA expression level ratios in the choroid. n = 10 per group. * p < 0.05, ** p < 0.01, and **** p < 0.0001. Group comparisons were analyzed by analysis of variance and Tukey’s post hoc test. The values are represented as mean ± SE.