Table 8.

PSMA PET Progression (PPP) criteria for treatment response evaluation in patients with metastatic prostate cancer.

PPP Criteria
Category	Progression Criterion	Description and Recommendations
A	≥2 new PSMA-positive lesions	≥2 new PSMA-positive distant lesions
B	1 new PSMA-positive lesion	1 new PSMA-positive lesion plus clinical or laboratory data. Recommended confirmation by biopsy or correlative imaging within 3 months from PSMA
C	No new lesions but size increase	Increase by ≥30% in size or uptake plus consistent clinical or laboratory data. Confirmation by biopsy or correlative imaging within 3 months of PSMA PET

Adapted from Fanti et al. [14]. Abbreviations: PPP, PSMA PET Progression; PSMA, prostate-specific membrane antigen; PET, positron emission tomography.