Table 15.
[18F]NaF response criteria in primary bone tumors (NAFCIST).
| NAFCIST | |
|---|---|
| Category | Description |
| Complete metabolic response | Normalization of all lesions (target and non-target) to SUV less than the mean skeletal SUV and equal to the normal surrounding tissue SUV; verification with a follow-up study in 1 month if anatomical criteria indicate disease progression. |
| Partial metabolic response | >30% decrease in SUVpeak *; verification with follow-up study if anatomical criteria indicate disease progression. |
| Stable metabolic disease | Does not meet other criteria. |
| Progressive metabolic disease | >30% increase in SUVpeak *; >75% increase in total [18F]NaF burden of the five most active lesions; visible increase in the extent of [18F]NaF uptake; new lesions; verification with follow-up study if anatomical criteria indicate complete or partial response. |
* Primary outcome determination is measured on the single most active lesion on each scan (not necessarily the same lesion). Secondary outcome determination is the summed activity of up to the five most intense lesions (no more than two lesions per organ). Adapted from Kairemo et al. [20]. Abbreviations: NAFCIST, Na18F PET response Criteria in Solid Tumors; Na18F, sodium fluoride-18; SUV, standardized uptake value.