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. 2023 Mar 3;15(3):832. doi: 10.3390/pharmaceutics15030832

Scheme 1.

Scheme 1

Top panel: the process of fabricating HMSNPs (H1) starting from a dense Stöber core. Bottom panel from left to right: the structure of the alkoxysilane precursors TEOS and BTEPDS, precursor ratios for outer shell layer of each nanoparticle with black circles representing 70% TEOS & 30% BTEPDS and red circles representing 100% BTEPDS, differentiating HMSNPs into layer-by-layer HMSNPs: H2 as double-layered particles; and H3 as triple-layered particles.