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. 2023 Mar 6;15(3):856. doi: 10.3390/pharmaceutics15030856

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Gene-hydrogel microenvironment for regeneration of intervertebral disc degeneration (IVDD). (a) The construction of gene-hydrogel microenvironment. (b) Agomir@PEG was injected into the intervertebral space to construct the gene-hydrogel microenvironment. (c–e) The multi-functions provided by the gene-hydrogel microenvironment, matching the regeneration of IVDD. Reprinted from Ref. [322] with permission from WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany, copyright 2020.