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. 2023 Mar 16;24(6):5704. doi: 10.3390/ijms24065704

Figure 2.

Figure 2

18F-MAPP imaging in a mouse model of myocardial infarction treated with PF-2999. (A) Representative CT, PET, and fused PET-CT images of MI mice treated with PF-2999 or vehicle (infarcted area outlined with dashed lines; blue arrow points to the infarct, and white arrow points to surgical injury). (B) 18F-MAPP uptake in mice treated with 50 mg/kg of PF-2999 showed a 40% reduction compared to that in the control group (*** p < 0.001, one-tailed t-test, n = 5 for the treatment group and 6 for control group). (C) 18F-MAPP uptake in mice treated with 15 mg/kg of PF-2999 showed a 30% of reduction versus that in the vehicle-treated group (* p < 0.05, one-tailed t-test, n = 4 for each group).