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MPO activity assay with mice treated with 15 mg/kg of PF-2999. (A) Intracellular MPO activity in mice treated with PF-2999 was significantly lower compared to that in the control group (** p < 0.01, n = 4 for each group, one-tailed t-test). (B) Extracellular MPO activity in mice treated with PF-2999 showed 38% reduction compared to that in the control group (ns = not significant, p = 0.17, n = 4 for each group, one-tailed t-test).
