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. 2023 Mar 15;14:1138255. doi: 10.3389/fendo.2023.1138255

Figure 3.

Figure 3

PRP treatment of spinal cord injury. (A-C) drNPC cultured on the two component SPRPix matrix (PRP hydrogel embedded into the rSS-PCL scaffold) demonstrated a high level of adhesion and neuronal differentiation: drNPC completely covered the entire SPRPix matrix surface and formed long βIII-tubulin- and MAP2- positive processes oriented along the spidroin microfibrils. (D) No directional growth was observed in scaffolds without PRP. (E–G) The expression of BDNF, NF-200 and GFAP genes was significantly increased after PRP and BMSCs were used together. Reproduced with permission from (77, 78). $ or $$ or $$$ P< 0.05 or P< 0.01 or P< 0.001 (PRP/BDNF-BMSCs vs. BDNF-BMSCs), # or ## or ### P< 0.05 or P< 0.01 or P< 0.001 (PRP/BDNF-BMSCs vs. PRP/BMSCs), +++ P < 0.001 (PRP/BDNF-BMSCs vs. BMSCs alone),& or && or &&&P < 0.05 or P < 0.01 or P < 0.001 (PRP/ BMSCs vs. BMSCs alone).