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. 2023 Mar 18;15(6):1470. doi: 10.3390/nu15061470

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(A) Serum sKlotho and FGF23 in control subjects and chronic kidney disease (CKD) patients distributed according to eGFR from KDIGO guidelines. Median are shown. ^a p < 0.05, ^aa p < 0.01, ^aaa p < 0.005 vs. Control, ^b p < 0.05, ^bb p < 0.01, ^bbb p < 0.005 vs. CKD-2/3a. Correlation between serum sKlotho and serum creatinine in (B) the individuals described in (A). Each shape represents Control (○), CKD-2/3a (■), CKD-3b (●), CKD-4 (▲) and CKD-5 (♦) values; and in (C) Sham-operated mice fed normal phosphorus (NP) (Reference) and CKD mice fed NP or high phosphorus (HP) diet for 14 weeks, each shape represents Reference (○), CRF+NP (●) and CRF+HP (■) values.