Table 1.
Weight and biomarkers of kidney dysfunction in the in vivo study.
| Reference (n = 8) |
CKD+NP (n = 6) |
CKD+HP (n = 7) |
|
|---|---|---|---|
| Final body weight (g) | 32.21 ± 5.73 | 27.23 ± 1.89 | 25.54 ± 2.86 aa |
| Creatinine (mg/dL) | 0.25 ± 0.04 | 0.34 ± 0.06 a | 0.37 ± 0.06 aaa |
| BUN (mg/dL) | 23.19 ± 4.46 | 41.67 ± 7.14 aaa | 36.45 ± 8.86 aaa |
| Calcium (mg/dL) | 9.13 ± 0.56 | 9.56 ± 0.73 | 9.67 ± 0.46 |
| Phosphorus (mg/dL) | 5.29 ± 1.23 | 5.81 ± 0.79 | 7.21 ± 1.66 a |
| PTH (pg/mL) | 172.68 ± 58.35 | 353.29 ± 121.95 a | 442.04 ± 219.37 aaa |
| FGF23 (pg/mL) | 196.75 ± 132.13 | 186.00 ± 75.42 | 1643.86 ± 892.96 aaa,bbb |
| 1,25(OH)2D3 (pg/mL) | 88.00 ± 29.25 | 104.71 ± 15.91 | 109.76 ± 20.30 |
| sKlotho (pg/mL) | 36.78 ± 14.81 | 7.33 ± 4.56 aa | 1.85 ± 1.85 aaa |
| Calciuria (mg/24 h) | 23.50 ± 15.41 | 26.50 ± 13.00 | 9.90 ± 6.82 aaa,bb |
| Phosphaturia (mg/24 h) | 7.20 ± 7.54 | 2.90 ± 6.40 | 788.20 ± 483.95 aa,bbb |
| Urine albumin (µg/24 h) | 32.14 [14.35–49.75] | 12.96 [8.37–29.19] | 100.85 [37.62–118.32] b |
| Urine Klotho (pg/24 h) | 2269 [1801–13,052] | 1592 [1158–24,249] | 537 [373–857] a,b |
| Urine Klotho (pg Klotho/mg urine creatinine) |
6384 [4988–64,903] | 5876 [4100–13,483] | 2365 [377–2482] a,b |
CKD, Chronic Kidney Disease; NP, normal phosphorus diet; HP, high phosphorus diet; Reference, Sham-operated fed NP. a p < 0.05, aa p < 0.01 and aaa p < 0.005, show differences between CKD either NP or HP and reference group; b p < 0.05, bb p < 0.01 and bbb p < 0.005, show differences between CKD+NP and CKD+HP. Values are expressed as Median [interquartile range] or mean ± standard deviation. Kruskal–Wallis and Dunn tests as post hoc analysis, with Bonferroni correction were used as statistical methods. Bold data represents significant differences.