Table 2.
Clinical and biochemical parameters and sKlotho in the CKD patients.
| Control (n = 38) |
CKD-2/3a (n = 11) |
CKD-3b (n = 12) |
CKD+NP (n = 6) |
CKD+HP (n = 7) |
|
|---|---|---|---|---|---|
| Age (years) | 66.50 ± 4.63 | 61.72 ± 10.11 | 67.33 ± 7.41 | 69.09 ± 8.94 | 68.78 ± 5.97 |
| BMI (kg/m2) | 27.19 ± 4.57 | 31.34 ± 4.70 | 26.79 ± 2.84 | 30.52 ± 6.60 | 26.74 ± 3.99 |
| Creatinine (mg/dL) | 0.83 (0.72–0.98) | 1.23 (1.19–1.50) aaa | 1.75 (1.63–1.84) aaa | 2.66 (2.30–2.95) aaa,b | 3.70 (3.41–4.48) aaa,bbb,c |
| eGFR (mL/min/1.73 m2) | 81.5 (75–87.8) | 49.0 (47.0–53.0) aaa | 39.0 (33.8–40.3) aaa | 23.0 (20.5–24.5) aaa,b | 12.0 (12.0–13.0) aaa,bbb,c |
| Total protein (mg/dL) | 70.70 ± 3.49 | 71.20 ± 3.08 | 69.45 ± 2.88 | 69.05 ± 3.56 | 68.50 ± 5.96 |
| Calcium (mg/dL) | 9.53 ± 0.27 | 9.53 ± 0.32 | 9.55 ± 0.37 | 9.66 ± 0.60 | 9.35 ± 0.45 |
| Phosphorus (mg/dL) | 3.64 (3.54–4.00) | 3.16 (3.54–3.53) a | 3.30 (2.69–3.47) aaa | 3.41 (3.10–3.88) | 4.09 (3.84–4.87) a,bbb,ccc,ddd |
| PTH (pg/mL) | 52.0 (41.5–60.5) | 56.0 (43.0–75.0) | 86.5 (71.8–117.5) aaa | 114.0 (71.5–198.5) aaa,bb | 176.0 (155.0–212.0) aaa,bbb,c |
| 1,25(OH)2D3 (pg/mL) | 45.56 ± 11.55 | 38.80 ± 11.50 | 29.13 ± 10.27 aaa | 38.57 ± 17.89 | 24.03 ± 12.14 aaa |
| FGF23 (pg/mL) | 55.2 (46.3–64.7) | 56.8 (52.1–62.8) | 134.6 (80.7–166.2) aaa,b | 143.8 (101.1–240.8) aaa,bb | 175.9 (141.2–1,689.0) aaa,bbb |
| sKlotho (pg/mL) | 809.2 (680.3–1042.2) | 670.6 (604.2–746.0) a | 632.2 (599.8–713.0) aa | 591.4 (517.2- 706.8) aaa | 585.80 (469.40–674.20) aaa |
| Urine creatinine (mg/dL) | 105.65 (74.63–150.80) | 44.80 (35.25–100.75) a | 95.95 (57.58–114.38) | 82.75 (56.75–95.73) | 47.20 (46.60–71.30) aaa |
| Proteinuria (g/L) | 0.07 (0.05–0.09) | 0.05 [0.03–0.16] | 0.44 (0.15–0.77) aaa,bb | 0.32 (0.09–0.94) aaa,bb | 0.58 (0.26–1.06) aaa,bbb |
| Urine Klotho (pg Klotho/mg urine creatinine) | 433.4 (189.1–726.9) | 1143.1 (539.4–2220) aa | 1055.1 (910.8–2,103.5) aaa | 1003.3 (849.2–2819.2) aaa | 1099.7 (905.9–1503) aaa |
CKD, Chronic Kidney Disease. a p < 0.05, aa p < 0.01 and aaa p < 0.001 vs. Control; b p < 0.05, bb p < 0.01, bbb p < 0.001 vs. CKD-2/3a; c p < 0.05, ccc p < 0.001 vs. CKD-3b; ddd p < 0.005 vs. CKD-4. Values are expressed as Median [interquartile range] or mean ± standard deviation. Kruskal–Wallis or ANOVA test and Dunn test or Tukey test as post hoc analysis, were used as statistical methods. Bold data represents significant differences.