Figure 1.

Overview of the 1D thrombolytic model. (a) Two-compartment PK-PD model. (b) Schematic of local PD model which couples 1D blood flow (in x-direction) with species transport and fibrinolytic reactions. The model solves clot lysis in an occluded artery where the red area indicates the clot with a porosity of ε_clot and the open area is clot-free with $\epsilon =1$. (c) Fibrinolysis mechanism on fibrin.