Table 2.

Common metabolic enzymes and receptors of different classes of bioactive lipids.

Enzyme/Receptor	EICs	ECBs	SPMs
PLA2	+	+	+
CYP450	+	+	+
12-LOX	+	+	+
COX-2	+	+	+
CB1	+	+	+
CB2		+	+
GPR18		+	+
TRPV1	+	+	+
BLT1	+		+

Abbreviations: EICs—eicosanoids; ECBs—endocannabinoids; SPMs—specialized pro-resolving mediators; PLA₂—phospholipase A₂; CYP450—cytochrome P450; 12-LOX—12-lipoxygenase; COX-2: cyclooxygenase-2; CB_1/2—cannabinoid receptor 1/2; GPR18—G protein-coupled receptor 18; TRPV1—transient receptor potential vanilloid-1; BLT1—leukotriene B₄ receptor.