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. Author manuscript; available in PMC: 2024 Mar 1.
Published in final edited form as: Adv Mater. 2023 Jan 11;35(10):e2208781. doi: 10.1002/adma.202208781

Figure 6. Primed MSCM coating mitigated BMP-induced inflammation, promoted macrophage polarization towards M2 phenotype, and enhanced MSC osteogenesis in vitro.

Figure 6.

(a) Schematics and timeline for evaluating Mφ polarization in response to BMP-2 and pMSCM coating. (b-c) Gene expressions of CD86, CD206 (b) and cytokine secretion (TNF-α and IL-10) (c). (d) Schematics and timeline for evaluating MSC osteogenesis in response to primed MSCM-coating and BMP-2 treatment. (e) Osteogenic gene expression of MSCs at week 2 in uncoated μRB scaffolds or MSCM-μRB scaffolds. (f, g) Representative images of ALP staining at week 1 (f) and ARS staining at week 4 (g). Scale bar: 1 mm. Data are represented as mean ± S.D. (n = 4/group). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.