Figure 7. A schematic summary of primed MSCM-coated μRB scaffolds enhance bone regeneration through inducing regenerative immune response of both innate and adaptive immune cells, modulating the crosstalk between immune cells and MSCs, and synergizing with BMP-2.
Primed MSCM-coating contains ligands that promote Mφ polarization towards M2-like phenotype, induces Treg differentiation and TCD8+ apoptosis, and directly enhances MSC osteogenesis.