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. 2023 Mar 29;18(3):e0282301. doi: 10.1371/journal.pone.0282301

Table 3. Affected metabolic pathways in HA.

MapTitle P value Metabolites
Purine metabolism 0.084 Guanosine, Adenosine, Inosine
Regulation of lipolysis in adipocytes 0.095 Adenosine, Corticosterone
Biotin metabolism 0.194 Biotin
cGMP-PKG signaling pathway 0.194 Adenosine
Vascular smooth muscle contraction 0.194 Adenosine
Circadian entrainment 0.194 Melatonin
Parkinson’s disease 0.194 Adenosine
Prion diseases 0.194 Corticosterone
Morphine addiction 0.194 Adenosine
Alcoholism 0.194 Adenosine
Neuroactive ligand-receptor interaction 0.247 Adenosine, Melatonin
Histidine metabolism 0.351 1-Methylhistidine
Arachidonic acid metabolism 0.351 5-OxoETE
Drug metabolism—cytochrome P450 0.351 2,6-Xylidine
Sphingolipid signaling pathway 0.351 Adenosine
Taste transduction 0.351 D-Phenylalanine
Renin secretion 0.351 Adenosine
Tryptophan metabolism 0.369 Xanthurenic acid, Indole-3-acetic acid, Melatonin