Table 2.

Summary of the main characteristics of ongoing trials investigating the effects of healthy diet on NAFLD. Abbreviations: NAFLD: non-alcoholic fatty liver disease; MRI: Magnetic Resonance; T2DM: type 2 diabetes.

Identifier	Study Design	Population Health Status	Sample Size	Duration	Type of Intervention	Type of Control	Liver Endpoint
NCT05309642	Parallel control trial	36 BMI >25 kg/m2 and 36 BMI < 25 kg/m2	72	12 weeks	Very low calories ketogenic diet	Standard of care diet	Change on liver steatosis by MRI
NCT05275608	Parallel control trial	BMI > 30–40 kg/m2 NAFLD T2DM	20	90 days	Very low calories ketogenic diet	Hypocaloric Mediterranean diet	Change in liver enzymes as secondary outcome
NCT04440540	Parallel control trial	Obese patients	40	1 year	Lifestyle program (diet not specified)	Standard of care diet	Change of intrahepatic triglycerides content in NAFLD
NCT05200585	Parallel	NAFLD	30	6 months	Behavioral: Healthy Liver/Hígado Sano program	Standard of care diet	MRI liver steatosis change
NCT04383951	Parallel	NAFLD	40	16 weeks	Ketogenic diet	Standard of care diet	MRI liver steatosis change
NCT05268042	Randomized controlled trial	Obese adolescents with NALF	80	6 months	Moderately carbohydrate-restricted diet	Fat-restricted control diet	MRI liver steatosis change
EudraCT:2021-000152-19	Randomized controlled trial	NAFLD and prediabetes patients	390	18 months	1.Med diet + metformin placebo pioglitazone placebo 2. Med diet + metformin + pioglitazone placebo 3. Med diet + metformin + pioglitazone	-	Evaluated witch model induce a greater regression of NAFLD