Table 4.
The ranges of biomarker concentrations and their corresponding RLs.
| Marker | Normal | Ranges of Absolute Parameter Values and Corresponding RL | |||||
|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | ||
| IL-6, pg/mL | <5.0 | 5–10 | 10–40 | 40–200 | 200–1000 | >1000 | - |
| IL-8, pg/mL | <10.0 | 10–25 | 25–100 | 100–500 | 500–2500 | >2500 | - |
| IL-10, pg/mL | <5.0 | - | 5–10 | 10–25 | 25–100 | 100–500 | >500 |
| TNFα, pg/mL | <8.0 | 8–16 | 16–40 | 40–160 | 160–800 | >800 | - |
| CRP, mg/dL | <1.0 | 1–3 | 3–15 | >15 | - | - | - |
Note. The mean of three maximal RL values for each factor gave the RL (1 to 5) for each patient, which was used for further calculation of the SI score. RL—reactivity level; IL—interleukin; TNF—tumor necrosis factor; CRP—C-reactive protein. It is reasonable to determine the RL by the degree (multiplicity) to which it exceeds the maximum permissible values of the norm. For the method we use, the normal limits are given in the Normal column, and the ranges for determining RL are given in absolute values (pg/mL and mg/mL).