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. 2023 Mar 29;9(13):eade8778. doi: 10.1126/sciadv.ade8778

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Fig. 5. — (A) Phylogenetic trees for viral genomes with the indicated resistance mutations (GISAID, 6 December 2022). Only the Omicron lineage is displayed for M49I because of the high frequency of this mutation. (B) Branches of the phylogenetic tree from (A) showing transmission of a Delta lineage isolate with ∆P168 likely from a single founder event. (C) Frequency of M^pro variants in Omicron lineage compared to all previous viral lineages. (D) Background luminescence as a proxy for protease activity of different M^pro variants on the P132H (Omicron) background using the live-cell Src-M^pro-Tat-fLuc assay. (E) Dose-response curves for nirmatrelvir and ensitrelvir inhibition of M^pro variants on the P132H (Omicron) background using the live-cell Src-M^pro-Tat-fLuc assay.