. 2023 Mar 29;9(13):eade8778. doi: 10.1126/sciadv.ade8778

Table 3. Resistance phenotypes of M^pro variants in replication-competent SARS-CoV-2.

M^pro variant	Nirmatrelvir	Ensitrelvir	Remdesivir
M^pro variant	IC₅₀ nM (95% CI)	IC₅₀ nM (95% CI)	IC₅₀ μM (95% CI)
WT	4.4 (3.4–5.5)	4.3 (2.9–5.8)	1.2 (0.59–2.5)
∆P168	7.0 (4.1–10.2)	3.6 (2.7–4.4)	1.1 (0.59–2.0)
A173V	36.0 (29.8–43.0)	7.8 (6.2–9.5)	1.3 (0.85–2.1)
∆P168/A173V	275 (161–465)	3.3 (2.1–4.8)	1.5 (0.78–2.9)

Table 3. Resistance phenotypes of Mpro variants in replication-competent SARS-CoV-2.