Figure 5.

Effect of natural mixture on in vitro colonic contractile responses. (A) Tachykininergic contractions mediated by NK1 of colonic longitudinal smooth muscle preparations taken from HFD- and SD-fed mice treated with natural mixture, Curcuma L., Cassia M. and P. emblica. (B) Contractions elicited by exogenous SP (1 μM) in colonic preparations taken from mice treated with natural mixture, Curcuma L., Cassia M. and P. emblica. Each column shows the mean ± S.E.M. (n = 6). One-way ANOVA and Tukey post hoc test results are as follows: *—p < 0.05 for significant difference vs. the SD group; ^a—p < 0.05 for significant difference vs. the HFD group. Abbreviations: HFD— high fat diet; SD—standard diet; SP—substance P.