Table 1.

Dietary fat intake and endometriosis.

Study Design	Subject	Results
		TF	SFAs	MUFAs	PUFAs n-3	PUFAs n-6	tFAs
Meta-analysis [45]	The association between i.a. fats and the risk of endometriosis among adult women; 8 publications, including 5 cohorts and 3 case-control.	No effect	↑	No effect	No effect	No effect	↑
Prospective study [19]	The relation between dietary fat intake and the risk of endometriosis; the experimental group n = 1199 women aged 25–42 years with endometriosis; median intake of total fat 24.2–38; SFAs 8.1–13.9; MUFAs 8.9–14.8; PUFAs 4.1–7.0; n-3, 0.4–0.8; n-6, 3.5–6.4; tFAs 0.9–2.3 % of energy.	No effect	No effect SFA; ↑ PA	No effect	↓	No effect	↑
Case-control [46]	Dietary risk factors, i.e., fats for endometriosis; the experimental group n = 284 women aged 20–65 years with endometriosis; median intake of total fat 54.8 g, SFAs 19.2 g, MUFAs 20.3 g, tFAs 3.2 g.	↓	↓	↓	-	-	↓
Case-control [47]	The relationship between food consumption and nutrient i.a. fat intake with risk of endometriosis; n = 156: n = 78 women with endometriosis and control group n = 78; the regression analyses (odds ratio).	No effect	-	↓ ↓ OA	↓	-	-
Case-control [48]	The relation between i.a fats and benign ovarian tumors (BOTs) and nutrients, primarily dietary fat; the experimental group n = 393 women with BOTs, n = 280 women with endometrial tumors; median intake of total fat 48.9 g, SFAs 18.9 g, MUFAs 19.9 g, PUFAs 10.3 g.	↑	↑	↑	↑	↑	-
Case-control [51]	The relation between dietary fat intake and the risk of endometriosis; the experimental group n = 25 women with stage I–IV endometriosis; median intake of SFAs 18.56 g, n-3 PUFAs 0.66 g; n-6 PUFAs 9.61 g.	-	No effect	-	↓	↓	-
In vitro study [36]	The effects of composition of n-3 and n-6 PUFAs on in vitro proliferation of endometrial cells and their production of the cytokine interleukin-8 (IL-8); endometrial cells from women with and without endometriosis.	-	-	-	↓	-	-

↓ decrease of endometriosis risk; ↑ increase of endometriosis risk.