Figure 4.

Alpha synuclein architecture. (A) Schematic representation of α-Syn primary sequence indicating the location of positively (blue) and negatively (red) charged amino acid, and KTKEGV repeats (green). Sequential domains and single-point mutations related to familial cases of PD are also indicated below the linear representation. (B–D) Structure of monomeric (B) and aggregated α-Syn forming different conformations or strains (C,D). In (B–D), the PDB files used are: 1XQ8, 6CU7, and 6CU8, respectively.