Table 1.
The genetics of PD. Summary of the different gene involved in PD and their role in the development of the pathology.
| Gene | Role in PD |
|---|---|
| SNCA (α-Synuclein) | Protein aggregation Prion-like transmission Synaptic function and dopamine transmission |
| GBA (Glucocerebrosidase) | Lysosome mediated autophagy pathway |
| LRRK2 | Neurite structure Protein and membrane trafficking Lysosome-mediated autophagy pathway Synaptic function and dopamine transmission |
| MAPT (Tau) | Protein aggregation Neurite structure |
| VPS35 | Protein and membrane trafficking Lysosome-mediated autophagy pathway |
| DNAJC13 (REM-8) | Protein and membrane trafficking Lysosome-mediated autophagy pathway |
| GAK | Protein and membrane trafficking |
| RAB7L1 | Protein and membrane trafficking |
| RAB39B | Protein and membrane trafficking |
| Parkin | Ubiquitin-mediated proteasome Mitochondrial dysfunction and mitophagy |
| FBX07 | Ubiquitin-mediated proteasome |
| SCA3 (Ataxin-3) | Ubiquitin-mediated proteasome |
| PINK1 | Mitochondrial dysfunction and mitophagy |
| DJ-1 | Mitochondrial dysfunction and mitophagy |
| CHCHD2 | Mitochondrial dysfunction and mitophagy |
| POLG1 | Mitochondrial dysfunction and mitophagy |
| SREVF1 | Mitochondrial dysfunction and mitophagy |
| ATP12A2 | Lysosome-mediated autophagy pathway |
| SCARB2 (LIMP-2) | Lysosome-mediated autophagy pathway |
| SYNJ1 (Synaptojanin 1) | Synaptic function and dopamine transmission |
| GCH1 | Synaptic function and dopamine transmission |
| STX1B (Syntaxin-1B) | Synaptic function and dopamine transmission |