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. 2023 Feb 23;11(3):524. doi: 10.3390/vaccines11030524

Figure 1.

Figure 1

Schematic depicting the vaccination protocol. Group I-I (n = 15) was vaccinated with two doses of inactivated SARS-CoV-2 vaccine (28-day interval), and groups I-I-m (7 d), I-I-m (14 d) and I-I-m (21 d) (n = 15 per group) were, respectively, vaccinated with the third dose of mRNA booster on days 7, 14 and 21 after the second dose. Group m (n = 10) was vaccinated with a dose of mRNA vaccine, and groups m-m (3 d), m-m (7 d), m-m (14 d) and m-m (21 d) (n = 10 per group) were vaccinated with the second dose of mRNA booster on days 3, 7, 14 and 21. Control mice were injected with phosphate-buffered saline (PBS) alone. Spleens of immunized animals were collected on the 3rd, 7th, 14th, 21st and 28th days after the last immunization for an ELISpot assay. Serum samples were collected on the 3rd and 28th days for ELISA and neutralizing antibody assays (n = 2–3 per group).