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. 2023 Mar 14;11(3):658. doi: 10.3390/vaccines11030658

Table 1.

Shows the chemical structures of different lipids used in LNPs for mRNA delivery.

Lipid Function Ref
Cationic ionizable lipids
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OF-Deg-Lin		 Selective delivery of mRNA into B lymphocytes [31]
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OF-C4-Deg-Lin		 Selective delivery of siRNAs and mRNAs [32]
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FTT5		 In vivo delivery of mRNA encoding human factor VIII and base editing components [33]
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Dlin-MC3-DMA		 Used in albumin receptor-mediated delivery of mRNA to the liver [34]
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OF-02		 Enhanced hepatic mRNA delivery [35]
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A6		 Albumin receptor mediated mRNA delivery [34]
Neutral/helper lipids
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DSPC		 Used in mRNA vaccines and vaccine candidates, including COVID-19. [6]
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DOPE		 Delivery of a variety of nucleic acids. [25]
PEG lipids
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PEG2000-DMG		 Used in mRNA vaccines and vaccine candidates, including COVID-19. [6]
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ALC-0159		 Delivery of mRNA vaccines. [6]