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. 2023 Mar 14;11(3):658. doi: 10.3390/vaccines11030658

Table 2.

FDA approved COVID-19 mRNA vaccines [71,72].

Name mRNA Specific to LNP Composition Adverse Effects
BNT162b2 Spike glycoprotein of SARS-CoV-2 lipids ((4-
hydroxybutyl)azanediyl)
bis(hexane-6,1-
diyl)bis(2-
hexyldecanoate), 2
[(polyethylene glycol)-
2000]-N,Nditetradecylacetamide,
1,2-distearoyl-snglycero-
3-phosphocholine, and
cholesterol), potassium
chloride, monobasic
potassium phosphate,
sodium chloride, dibasic
sodium phosphate
dihydrate, and sucrose
Myocarditis
Pericarditis
mRNA-
1273
Spike glycoprotein of SARS-CoV-2 LNP: Proprietary Ionic lipid
SM-102, polyethylene
glycol (PEG) 2000,
dimyristoylglycerol
(DMG), cholesterol, 1,2-
distearoyl-sn-glycero-3-
phosphocholine
[DSPC]), tromethamine
hydrochloride, acetic
acid, sodium acetate,
and sucrose
Myocarditis
Pericarditis
LUNARCOv-
19
(ARCT-
021)
Self-replicating
mRNA specific to Spike glycoprotein of SARS-CoV-2
Arcturus Therapeutics
proprietary ionizable
lipid, DSPC, cholesterol,
and PEG2000-DMG
dissolved in ethanol
NA

NA: not available.