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. 2023 Feb 24;15(3):627. doi: 10.3390/v15030627

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Baseline correlations between antibodies against common human coronavirus (HCoVs), SARS-CoV-2 spike-specific (IgG, IgA, and IgM) antibodies, neutralizing antibodies (NAB), specific memory B-cells (MBCs) and IgG+, IgA+, and IgM+ MBCs isotypes, CD4+ and CD8+ T-cell responses to SARS-CoV-2 spike (S), membrane (M), and nucleocapsid (N) proteins. (A) Spearman test heatmap analysis of the different variables in unexposed subjects with cross-reactivity. (B) Spearman test heatmap of the different variables in convalescent individuals. The grey color represents a positive correlation and the red color a negative correlation. The intensity of the color indicates the R² coefficient. Statistically significant when p < 0.05. * = p < 0.05, and ** = p < 0.01.