Table 1.
ECG changes associated with prophylactic and therapeutic regimens with CCrP.
| Prophylactically Administered CCrP | Therapeutically Administered CCrP | |||||
|---|---|---|---|---|---|---|
| Saline/Control | ISO + Saline | ISO + CCrP (0.8 g/kg/day) |
Saline/Control | ISO + Saline | ISO + CCrP (0.8 g/kg/day) | |
| QT (ms) | 138.3 ± 4.41 | 260.0 ± 11.55 * | 160.0 ± 5.77 # | 156.70 ± 8.8 | 240.0 ± 5.7 * | 170.7 ± 15.72 # |
| QRS (ms) | 35.33 ± 1.76 | 53.67 ± 4.48 * | 36.67 ± 2.90 # | 38.0 ± 1.15 | 59.3 ± 2.40 * | 41.33 ± 3.52 # |
| HR (bpm) | 350.0 ± 5.77 | 277.0 ± 5.87 * | 326.3 ± 10.87 # | 340.0 ± 5.7 | 278.3 ± 6.00* | 329.3 ± 9.82 # |
Data are presented as mean ± S.E.M. of 4–6 rats. *: statistical significance (p < 0.05) compared to the saline/control group. #: statistical significance (p < 0.05) compared to the ISO + saline group. ANOVA: one-way analysis of variance. ISO: isoproterenol; CCrP: cyclocreatine phosphate; and HR: heart rate.