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. 2023 Mar 7;28(6):2445. doi: 10.3390/molecules28062445

Table 2.

Stability tests of compounds 15–18.

Compound H2O [a], t1/2 [b] pH 7.4, [a] t1/2 [b] Plasma, [a] t1/2[b]
15 99%, >48 h 94%, >48 h 95%, >24 h
16 99%, >48 h 95%, >48 h 89%, >24 h
17 99%, >48 h 95%, >48 h 89%, >24 h
18 99%, >48 h 92%, >48 h 84%, >24 h

(a) Value expressed as percentage of unmodified compound after 48 h (water and pH 7.4 solution) or 24 h (plasma) of incubation. (b) Half-life (t1/2) expressed as the amount of time it takes before half of the drug is degraded.