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. 2023 Jan 9;123(4):402–414. doi: 10.1055/a-1981-1763

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The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ )

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.

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Fig. 2 — Peak height and endogenous thrombin potential as a function of DOAC concentrations in Adage patients and in normal pooled plasma samples spiked with DOAC, using STG-Thrombo-Screen reagent in the absence of thrombomodulin, and inhibition percentage in the presence of thrombomodulin. Absolute values of TG parameters in the absence of thrombomodulin (TM) (left) and percentage of inhibition in the presence of TM (right). Samples from patients receiving 10, 15, or 20 mg of rivaroxaban o.d. are represented with yellow, red, and grey circles, respectively. Samples from patients receiving 2.5 or 5 mg of apixaban b.i.d. are represented with blue and grey circles, respectively. Samples from pooled normal plasma spiked with DOAC at varying concentrations are represented with green diamonds. ³⁵ b.i.d., twice daily; DOAC, direct oral anticoagulant; o.d., once daily; TG, thrombin generation.