Fig. 4.

Young human plasma-derived exosomes reduce brain injury and cell ferroptosis after ICH.

(A) HE staining images showing the gross damage of the mouse brain from Sham, ICH and EXO administered groups. (B) Representative photomicrographs of Nissl staining from different groups. (C) Quantification of Nissl-positive neurons in experiment (B) (n = 3 animals for each group). (D) Representative immunofluorescent images of GPX4 around hematoma from different groups. (E) Quantitative analysis of GPX4 staining (Scale bars = 50 μm, n = 4 animals for each group). (F) Transmission electron microscopy images showing the changes of mitochondria from different groups. Scale bars = 500 nm, n = 3 animals for each group, **p < 0.01, ***p < 0.001 for ICH vs. sham; ^#p < 0.05, ^##p < 0.01 for ICH + EXO vs. ICH + Vehicle.